Work

A potent phenylalkylamine disrupts mycobacterial membrane bioenergetics and augments bactericidal activity of bedaquiline

Year: 2025

Type: article

Abstract: biochemical and genetic assays, the bactericidal activity of the analog is attributed to the perturbation of membrane bioenergetics and disruption of mycobacterial respiration. Overall, its promising activity profile, mode of action and synergistic interaction with bedaquiline support further exploration of the phenylalkylamine scaffold as a valued source of potential leads for antimycobacterial drug discovery.

Source: iScience

DOI: 10.1016/j.isci.2025.112915

Authors: Zheng Yen Phua, Ming Li, Azhar Ali, Cedric Cheng Sheng Cheong, Kai Jie Goh, Marcus Yi Kang Seto, Amos Shi Ying Ng, Jickky Palmae Sarathy, Boon Cher Goh, Mei Lin Go, Wai Keung Chui, Thomas Dick, Yulin Lam

Institutions: National University of Singapore, Cancer Science Institute of Singapore, Hackensack Meridian Health

Language: English

Topic: Tuberculosis Research and Epidemiology

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,240

Funders: Ministry of Education - Singapore, National Institutes of Health, National Institute of Allergy and Infectious Diseases

Awards: G2338417628, G6840109849, G6942164823

OpenAlex ID: W4411399222

FWCI: 1.422

Cites: 54

Cited by: 2

Related to: 10