Work

β-Cyclodextrin-conjugated butein as a selective electrochemical molecular trafficking system for bilastine

Year: 2025

Type: article

Abstract: Simple method for monitoring the therapeutic efficient concentration of anti-histamine drug, bilastine (BIL), is essential for rationalizing allergy and respiratory therapy. Herein, an external redox-mediator free molecular trafficking approach was developed using conjugated oligosaccharide-polyphenol system, β-cyclodextrin-butein (BCD-Bt). Mechanism behind the molecular loading of BIL within the hydrophobic cavity of BCD simultaneously enabling the redox-active signal transduction from the conjugated Bt are explored using cyclic and differential pulse voltammetric analyses. BCD-Bt sensor platform exemplified the selective loading of analyte BIL with a reliable detection linearity (nm to μM, R 2 = 0.981) and limit feasible for salivary therapeutic drug monitoring. Synergistic optical absorbance and emission-based molecular trafficking test further complements the multi-modal functionality of the demonstrated BCD-Bt in other similar molecular assays.

Source: Biosensors and Bioelectronics X

DOI: 10.1016/j.biosx.2025.100647

Authors: Ramya Kanagaraj, Shanmugam SenthilKumar, Gururaja Perumal Pazhani, Murugan Veerapandian

Institutions: Central Electrochemical Research Institute, Academy of Scientific and Innovative Research, SRM Institute of Science and Technology

Language: English

Topic: Electrochemical sensors and biosensors

Subfield: Electrical and Electronic Engineering

Field: Engineering

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,490