Work

Targeting smouldering neuroinflammation in multiple sclerosis: insights from tolebrutinib clinical trials

Year: 2025

Type: article

Abstract: The quest to mitigate disability progression in multiple sclerosis (MS) has long been hindered by our limited understanding of chronic or smouldering neuroinflammation and its drivers. Recent pathological and biomarker data indicate that chronic neuroinflammation, characterised by persistent microglial activation, oxidative injury, iron and glutamate toxicity, mitochondrial dysfunction, and axonal neurodegeneration, plays a crucial role throughout the course of MS.1 Current disease-modifying therapies (DMTs) predominantly target acute inflammatory events but fail to adequately address these chronic mechanisms.

Source: The Lancet Regional Health - Europe

DOI: 10.1016/j.lanepe.2025.101359

Authors: Maria Trojano, Damiano Paolicelli

Institution: University of Bari Aldo Moro

Language: English

Topic: Multiple Sclerosis Research Studies

Subfield: Pathology and Forensic Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $4,930