Work

Delivery of crocetin by grafting onto the surface of poly-aminopropylmethyl-silsesquioxane: Biocompatibility and wound healing ability assessment

Year: 2025

Type: article

Abstract: poly-aminopropylmethyl-silsesquioxane (PAMSQ) has been prepared and it was used to graft crocetin. PAMSQ was characterized by UV–Vis, FT-IR, and SEM-EDS analyses, which confirmed the successful grafting of crocetin onto the surface of PAMSQ. Blood compatibility and MTT assay on the 3 T3 cell line confirmed the biocompatibility of this product. Therefore, the effect of the prepared sample was investigated on healing the 1.50 × 1.50 cm 2 induced wound in rats. The results of H&E and MT staining established acceptable effect of this sample on lowering the healing period by increasing the rate of collagen production.

Source: Results in Chemistry

DOI: 10.1016/j.rechem.2025.102459

Authors: Ali Abbasi, Mahdi Mirzaee, Majid Salehi, Moslem Jafari Sani, Masoomeh Faghani

Institutions: University of Shahrood, Shahroud University of Medical Sciences

Language: English

Topic: Wound Healing and Treatments

Subfield: Rehabilitation

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,870