NEUROMODULATION OF THE PRE-FRONTAL CORTEX BY rTMS AND NEUROFUNCTIONAL TRAINING IN CHILDREN WITH AUTISM SPECTRUM DISORDER: RANDOMIZED CONTROLLED DOUBLE-BLIND CLINICAL TRIAL EUROMODULATION OF THE PRE-FRONTAL CORTEX THROUGH rTMS AND NEUROFUNCTIONAL TRAINING
Year: 2025
Type: article
Abstract: The objective of the study project is to compare the functional effects of ten sessions of neurofunctional training associated with repetitive transcranial magnetic stimulation (rTMS) on the active and placebo dorsolateral prefrontal cortex in children with ASD. This is a randomized, placebo-controlled, double-blind clinical trial involving 24 children diagnosed with ASD, aged between three and eight years. The children will be randomly allocated into two groups: Experimental group - neurofunctional training and active rTMS, and Control group - neurofunctional training and placebo rTMS. The participants will be evaluated one week before the intervention, one week and one month after the end of the interventions, using the Childhood Autism Rating Scale, the Autism Classification System: Social Communication, timed up and go, the 10-meter walk test, the Pediatric Balance Scale, and the Participation and Environment Measure for Children and Youth. The interventions will be held five times a week, carried out over two consecutive weeks. rTMS will be applied to the left dorsolateral prefrontal cortex for 20 minutes, at a high frequency (5Hz). After the application of rTMS, the participants will undergo neurofunctional training for 20 minutes. The neurofunctional training will consist of an activity circuit (10 minutes) and treadmill gait training (10 minutes). The results will be statistically analyzed assuming a significance level of p≤0.05.
Source: CIPEEX
Authors: Marcela de Oliveira Araújo, Sara Viana de Abreu Silva, Paula Soares da Silva, Giselle Araujo Ferreira, Marcele Paganoto Garcia Rodrigues da Silva, Amanda Macedo de Freitas Souza Ramos, Rafael dos Anjos Silva, Caroline Priscila de Oliveira, Luanda André Collange
Institution: Universidade Evangelica de Goiás
Language: English
Subfield: Neurology
Field: Neuroscience
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W4411399772