Bioinspired supramolecular fibrillization enables stretchable and biodegradable piezoelectric bioelectronics
Year: 2025
Type: article
Abstract: Bioinspired piezoelectricity is extensively explored for diverse bio-machine interface and biomedical engineering applications. Nevertheless, state-of-the-art bio-piezoelectricity mainly focuses on crystallization. Yet, crystalized structures exhibit several shortcomings, including limited biocompatibility or biodegradability along with intrinsic non-stretchability. Herein, peptides fibrillization is reported to present inherent bio-piezoelectricity. Upon forming double-network framework with silk fibroin, fibrous peptide piezogels of innate biocompatibility and biodegradability are achieved, showing a programmable piezoelectricity. In particular, the bioinspired supramolecular piezogel can linearly respond to external compression and stretching in large force regions, extensively expanding the application potential bio-piezoelectricity. Upon designing a "W"-shaped structural conformation, a peptide fibrous piezogel-based piezoelectric sensor is shown to be used for detection of limb movements and subcutaneous implantation of the bioinspired piezoelectric electronics, realizing in situ and real-time monitoring of stimuli responses. The findings suggest the promising potential of peptide fibrillization-based bio-piezoelectricity for diverse bio-machine interface and biomedical engineering applications.
Source: Science Advances
Authors: Haoran Wu, Hao Lyu, Hongbo Jiang, Yancheng Wang, Rusen Yang, Syed A. M. Tofail, Hai Xu, Chengchen Guo, Deqing Mei, Ehud Gazit, Kai Tao
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $4,500
OpenAlex ID: W4411401756