Work

Non-HDL/HDL cholesterol ratio (NHHR) as a novel predictor of gestational diabetes mellitus: a NHANES-based cross-sectional study

Year: 2025

Type: article

Abstract: PURPOSE: To investigate the association between the non-HDL/HDL cholesterol ratio (NHHR) and gestational diabetes mellitus (GDM) risk, and assess NHHR's predictive utility as a novel biomarker in U.S. pregnant women. PATIENTS AND METHODS: A cross-sectional analysis of 1590 pregnant women from NHANES (1999-2018) was conducted. GDM was defined as fasting glucose ≥5.1 mmol/L. NHHR was calculated as (total cholesterol - HDL-C)/HDL-C. Multivariable logistic regression, restricted cubic spline (RCS) models, and ROC analysis were used to evaluate associations, threshold effects, and diagnostic accuracy, incorporating NHANES sampling weights. RESULTS: for interaction > 0.05). NHHR demonstrated limited standalone diagnostic accuracy (AUC = 0.549, 95% CI: 0.510-0.587). CONCLUSION: While NHHR demonstrates limited standalone diagnostic accuracy (AUC = 0.549), its specificity for metabolic dysregulation suggests potential as a complementary biomarker in multi-parameter models.

Source: The Journal of Maternal-Fetal & Neonatal Medicine

DOI: 10.1080/14767058.2025.2516261

Authors: Fangfang Shan, Mengmeng Ye, Haochan Wu, Hui Zhou, Zhaoxia Zhong, Yibo Wu

Institution: Wuxi Fourth People's Hospital

Language: English

Topic: Gestational Diabetes Research and Management

Subfield: Obstetrics and Gynecology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

Funder: Wu Jieping Medical Foundation