Work

Combination Therapy with Endothelin Receptor Antagonist and Phosphodiesterase 5 Inhibitor in the Management of Severe Raynaud Phenomenon Associated with Systemic Sclerosis: A Case Report

Year: 2025

Type: article

Abstract: Systemic sclerosis (SSc) is a connective tissue disorder characterized by skin fibrosis, internal organ involvement, and vasculopathy. Raynaud phenomenon (RP), a vascular manifestation of SSc, is characterized by exaggerated vasoconstriction of peripheral blood triggered by cold and stress. RP can lead to prolonged digital ischemia, resulting in skin ulceration, known as digital ulcers. In severe cases, complications such as infection and tissue necrosis may occur, leading to autoamputation and permanent disability.

Source: JAAD Case Reports

DOI: 10.1016/j.jdcr.2025.06.002

Authors: Betul Macit, Hira Ghani, Anthony M. Reginato, Abrar A. Qureshi

Institution: Brown University

Language: English

Topic: Systemic Sclerosis and Related Diseases

Subfield: Pathology and Forensic Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $750