Work

The Role of Immune Checkpoint Inhibitors in Adrenocortical Carcinoma: Enhancing Post‐Surgical Outcomes and Overcoming Relapse

Year: 2025

Type: article

Abstract: Adrenocortical carcinoma (ACC) is a rare and aggressive cancer that's usually detected at an advanced stage and has a high recurrence rate despite surgical resection, making treatment challenging. Although mitotane is still the only approved treatment, its poor effectiveness has raised interest in immunotherapy with immune checkpoint inhibitors (ICIs) such as avelumab, nivolumab, and pembrolizumab. By addressing ACC's immune response, ICIs and surgery together are intended to improve post-operative results and lower recurrence.

Source: Medicine Advances

DOI: 10.1002/med4.70019

Authors: Jawairya Muhammad Hussain, Saim Mahmood Khan, Haiqa Sultan, Diya Rathi, Eyob Mekonnen Woldeyohannes, Zemichael Getu Alemayehu

Institutions: Karachi Medical and Dental College, Jinnah Sindh Medical University, Dow University of Health Sciences, Addis Ababa University

Language: English

Topic: Adrenal and Paraganglionic Tumors

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4411408313

FWCI: 0.892

Cites: 16

Cited by: 1

Related to: 10