Work

In Situ : Microbial Aerodynamic Microneedles for Targeted Drug Delivery Systems

Year: 2025

Type: article

Abstract: In situ microbial aerodynamic microneedles (MM-MNs) represent an autonomous transdermal drug delivery platform that utilizes the gas generated by microbial metabolism (e.g., H 2 , NO, and H 2 S) to propel drugs into deep tissues, surpassing the penetration limits of traditional microneedles reliant on external stimuli (heat/light/mechanical force). By leveraging controlled microbial metabolism, MM-MNs enable energy-independent, spatiotemporally precise delivery with enhanced targeting and bioavailability. Gas-driven propulsion combines with bioactive gas functions (e.g., NO-induced vasodilation and H 2 S-mediated anti-inflammation) to modulate disease microenvironments. The system’s biocompatibility (probiotic strains and Lactobacillus ) and scalability (cost-effective patch design) further support its potential for localized therapies (skin diseases and tumors) with minimized systemic exposure. This innovation bridges microbial biotechnology and precision medicine, offering a paradigm shift in transdermal delivery.

Source: Research

DOI: 10.34133/research.0775

Authors: Chenyu Zong, Fei Wang, Wenguo Cui

Institutions: Åbo Akademi University, Shanghai Jiao Tong University, Ruijin Hospital

Language: English

Topic: Advancements in Transdermal Drug Delivery

Subfield: Pharmaceutical Science

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,500