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Synthesis, Аntibacterial, Аntifungal, and Antioxidant Activity of New (Benzo)Imidazo[2,1-b][1,3]Thiazine Quaternary Salts

Year: 2025

Type: article

Abstract: A series of quaternary salts – 1-phenacyl(4-chlorophenacyl)-6-hydroxy-6,7-dihydro-5H-benzo[4,5]imidazo[2,1-b][1,3]thiazinium bromides 4a-f were obtained. Their structures were rigorously proven by the methods of 1H NMR, 13C NMR spectroscopy, and chromatography-mass spectrometry. All obtained compounds were tested in in vitro experiments for antibacterial, antifungal, and antioxidant activity. Bioscreening results showed that 1-(4-chlorophenacyl)-6-hydroxy-6,7-dihydro-5H-benzo[4,5]imidazo[2,1-b][1,3]thiazinium bromide 4f exhibits the highest antibacterial activity against the strain of gram-positive bacteria Staphylococcus aureus ATCC 25923 at a concentration of 125 μg/mL, and salts 4a, c, f – against strains of gram-negative bacteria Pseudomonas aeruginosa ATCC 27853 at a concentration of 62.5 μg/mL. In turn, salt 4c demonstrated the best rate of radical inhibition at the level of 69.3%.

Source: Chemistry & Chemical Technology

DOI: 10.23939/chcht19.02.242

Authors: Nataliia Slyvka, Lesya Saliyeva, Mariia Litvinchuk, Alina Grozav, Nina Yakovychuk, Mykhailo Vovk

Institutions: Lesya Ukrainka Volyn National University, National Academy of Sciences of Ukraine, Institute of Organic Chemistry, Bukovinian State Medical University

Language: English

Topic: Phenothiazines and Benzothiazines Synthesis and Activities

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W4411411985