Work

Changes in Serum PINP and β-CTX Levels before and after Glucocorticoid Therapy in Patients with Systemic Lupus Erythematosus and Their Clinical Significance

Year: 2025

Type: article

Abstract: This study aims to elucidate the characteristics of bone metabolic imbalance and its clinical significance as reflected by the changes in serum PINP and β-CTX levels before and after glucocorticoid therapy in patients with systemic lupus erythematosus (SLE). The results indicate a rapid decline in PINP levels during the early phase of treatment, suggesting a marked suppression of bone formation, while β-CTX levels, though showing delayed elevation in some cases, remained indicative of active bone resorption overall, demonstrating that a bidirectional imbalance in bone metabolism had already developed as a systemic stress response in the short term. Analysis of these biomarkers contributes to the establishment of individualized bone health monitoring models for SLE patients, providing an evidence-based foundation for risk management during glucocorticoid therapy.

Source: MEDS Public Health and Preventive Medicine

DOI: 10.23977/phpm.2025.050119

Authors: Hu Yue, Duan Lihua

Institutions: Nanchang University, Jiujiang First People's Hospital, Jiangxi Provincial People's Hospital

Language: English

Topic: Bone health and osteoporosis research

Subfield: Orthopedics and Sports Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W4411413933