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Microwave‐Assisted One‐Pot Synthesis of 1,5‐Benzodiazepine Derivatives Using Novel ZnFe2O4 .Cu( OH )2 Magnetic Nanocomposite as Heterogeneous Catalyst and Their Theoretical Studies as Antifungal Agents

Year: 2025

Type: article

Abstract: ABSTRACT Incredible applications of 1,5‐benzodiazepine derivatives in the pharmacological and biological world have encouraged us to synthesize the series of novel 2,4‐disubstituted‐1,5‐benzodiazepine derivatives in one pot using reusable ZnFe2O4.Cu(OH)2 magnetic nanocomposite as a heterogeneous catalyst under microwave irradiation with a yield range of 70%–93%. The novel ZnFe2O4.Cu(OH)2 catalyst was characterized by XRD and TEM. The synthesized 1,5‐benzodiazepine derivatives are further investigated for theoretical DFT observations using Spartan‐14 software, Autodock Vina, and Discovery Studio software to study their antifungal activity effectiveness towards CaCYP51 (PDB ID‐5EQB) protein and observed that almost all compounds exhibit antifungal activity.

Source: Journal of Heterocyclic Chemistry

DOI: 10.1002/jhet.4954

Authors: Anjaneyulu Bendi, Anirudh Singh Bhathiwal, Aditi Tiwari, G. B. Dharma Rao, Mozhgan Afshari

Institutions: Presidency University, Banaras Hindu University, Islamic Azad University, Shoushtar Branch

Language: English

Topic: Synthesis and pharmacology of benzodiazepine derivatives

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: bronze

Funders: Islamic Azad University, Indian Agricultural Research Institute, Presidency University

OpenAlex ID: W4411422098

FWCI:

Cites: 28

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Related to: 10