Work

Synthesis of Radioiodinated Silica-Coated Magnetic Nanoparticles as SPECT/MR Dual-Modality Probe for Bone Imaging

Year: 2025

Type: article

Abstract: Purpose A reliable imaging probe is essential for the accurate diagnosis of diseases and to support effective therapeutic decision-making. Different nanoparticles based multimodal probes have been studied for bone imaging. This work focuses on synthesizing of radiolabeled iron oxide magnetic nanoparticles as a promising dual modality bioprobe (SPECT/MR) for bone imaging. Methods In this work, silica coated magnetic nanoparticles (SiO2@MNPs) were synthesized. Radioiodination of SiO2@MNPs with iodine − 131 was performed via the Finkelstein reaction to produce a prospective radioiodinated MNPs for bone targeting. Results The radioiodinated NPs were obtained in high radiochemical purity (about 98.5 ± 0.5%) by magnet separation. The aqueous dispersion of the radioiodinated silica coated MNPs (131I-SiO2@MNPs) exhibited adequate in-vitro stability and biocompatibility. Biodistribution study results after intravenous injection of (131I-SiO2@MNPs) in normal mice revealed the high bone targeting efficiency of the radiolabeled NPs (Cmax= 6± 0.5% ID/g at tmax= 2 h post injection). Magnetization properties measurements proved the preservation of the magnetic properties of SiO2@MNPs after the iodination process retaining its effectiveness as MRI contrast agent. Conclusion Based on to the results of this study, 131I-SiO2@MNPs could be considered as a promising candidate for SPECT/MR dual bone imaging. Graphical Abstract

Source: Journal of Pharmaceutical Innovation

DOI: 10.1007/s12247-025-10011-w

Author: Noha A. Bayoumi

Institution: Egyptian Atomic Energy Authority

Language: English

Topic: Radiopharmaceutical Chemistry and Applications

Subfield: Radiology, Nuclear Medicine and Imaging

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,990