Consensus on the Management of Anesthetic Agents During Digestive Motility Measurements and Proposal of a Standardized Protocol for Anesthesia (French Neuro Gastroenterology Group GFNG and Committee of Anesthetic French Experts)
Year: 2025
Type: article
Abstract: INTRODUCTION: Techniques for measuring digestive motility are becoming increasingly precise and enable therapeutic interventions. However, while most of these interventions require general anesthesia, there is limited data on the impact of anesthetic agents on these measurements, and no standardized anesthesia protocol currently exists to guide such procedures. Our working group carried out two Delphi processes involving experts in neurogastroenterology and anesthesiology to reach a consensus on which drugs affect these measurements and to establish an anesthesia protocol. METHOD: Two expert groups were formed, comprising 13 neurogastroenterology experts from the French Neuro-Gastroenterology Group (GFNG) and 15 full- or associate professors in anesthesia and intensive care. The first Delphi process involved the neurogastroenterologists and aimed to identify which anesthetic drugs influenced digestive pressure measurements. The second Delphi process, involving anesthetists, sought to develop an anesthesia protocol. Each expert indicated their level of agreement with each statement using a 6-point Likert scale. A statement was endorsed when at least 80% of experts agreed with it. The strength of evidence for each statement was evaluated using the GRADE system. RESULTS: The Delphi process with neurogastroenterologists was conducted over three rounds and ultimately resulted in 91 amendments. The second Delphi process with anesthetists took place over two rounds and included 28 amendments, leading to the development of an anesthesia protocol. CONCLUSION: To our knowledge, this work is the first to establish an expert consensus on anesthetic agents that can affect digestive motility measurements and to propose an anesthesia protocol that accounts for the needs of neurogastroenterologists.
Source: Neurogastroenterology & Motility
DOI: 10.1111/nmo.70098
Authors: Domitille Renard, Thomas Clavier, Osama Abou‐Arab, Gérard Amarenco, Emmanuel Besnier, Alice Blet, Matthieu Boisson, Charlène Brochard, Benoit Coffin, Audrey De Jong, Denis Frasca, Marc Garnier, Aurelie Gouel, Jérémie Jacques, Arthur James, Yoann Launey, Anne‐Marie Leroi, Chloé Melchior, Daphné Michelet, François Mion, Maxime Nguyen, Emmanuel Rineau, Amélie Rollé, Sabine Roman, Stéphanie Sigaut, Heithem Soliman, Fabien Wuestenberghs, Frank Zerbib, Guillaume Gourcerol, Charlotte Desprez
Institutions: Centre Hospitalier Universitaire de Rouen, Inserm, Endothélium, valvulopathies et insuffisance cardiaque, Université de Rouen Normandie, Centre Hospitalier Universitaire Amiens-Picardie, Sorbonne Université, Pitié-Salpêtrière Hospital, Groupe de Recherche Clinique en Neuro-urologie, Lyon 1 Université, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, Centre de Recherche en Cancérologie de Lyon, Université de Poitiers, Centre Hospitalier Universitaire de Poitiers, Pharmacologie des anti-infectieux et antibiorésistance, Hôpital Pontchaillou, Université de Rennes, Nantes Université, Université Paris Cité, Hôpital Louis-Mourier, Centre National de la Recherche Scientifique, Université de Montpellier, Physiologie et Médecine Expérimentale du Coeur et des Muscles, Centre Hospitalier Universitaire de Montpellier, Hôpital Saint Eloi, Assistance Publique – Hôpitaux de Paris, Hôpital Tenon, Centre Hospitalier Universitaire de Limoges, Groupe de recherche clinique en anesthésie réanimation médecine périopératoire, Centre Hospitalier Universitaire de Rennes, Nutrition, Inflammation et axe Microbiote-Intestin-Cerveau, Centre Hospitalier Universitaire de Reims, Cognition, Santé, Société, Université de Reims Champagne-Ardenne, Laboratoire des applications Thérapeutiques des Ultrasons, CHU Dijon Bourgogne, Centre Hospitalier Universitaire d'Angers, Mitochondrial and Cardiovascular Physiopathology, Université d'Angers, Hôpital Beaujon, AgroParisTech, Université Paris-Saclay, Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement, Université Sorbonne Paris Nord, Hôpital Avicenne, Physiologie de la Nutrition et du Comportement Alimentaire, Centre Hospitalier Universitaire de Bordeaux, Centre d'Investigation Clinique Plurithématique de Bordeaux
Language: English
Subfield: Anesthesiology and Pain Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,640
OpenAlex ID: W4411430475