Work

A Novel Capillary Zone Electrophoresis Technique for Pharmacokinetic Studies on Porphyrin-C60 Based Neuroprotectors. Preliminary Report

Year: 2025

Type: article

Abstract: A novel, fast-n-reliable, Quartz capillary silica zone electrophoresis required to upgrade an arsenal of analytical tools for current pharmacokinetics studies on porphyrin-fullerene nanoparticles has been proposed. The fullerene(C60)-tetra(p-hydroxyphenyl)porphyrin structures, known for their capabilities to paramagnetic 25Mg2+ delivery, were found quantitatively detectable in a total rat brain cytosol (S125) fraction, once these nanocationites administered in a single, either 1.0 mg/kg or 20.0 mg/kg, i.v. injection followed by 12 hrs long animal-drug exposition time. Driven by pressing needs in ongoing preclinical trial platform developments, the CZE track proposed might make an impact on both convenience and efficiency of pharmacokinetic estimate of medicinal nanocationites.

Source: Pharmacology &amp Pharmacy

DOI: 10.4236/pp.2025.166011

Authors: Alexander Bukhvostov, Anna Semenova, Olga Kamkina, Stanislav Arkhangelskiy, Dmitry A. Kuznetsov

Institution: Pirogov Russian National Research Medical University

Language: English

Topic: Microfluidic and Capillary Electrophoresis Applications

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: diamond

Funder: Ministry of Science and Higher Education of the Russian Federation