Year: 2025
Type: article
Abstract: 胃肠间质瘤(GISTs)是一种起源于消化道的稀有肿瘤，其恶性程度对患者的预后和治疗方案具有重要影响。近年来，随着分子生物学和肿瘤学的发展，研究者们逐渐认识到多种因素在GISTs的恶性程度中扮演着重要角色，包括基因突变、肿瘤大小、组织学特征等。然而，目前关于这些因素在GISTs恶性程度中的具体作用机制及其相互关系的研究仍然存在不少争议和不足。本文旨在综合分析目前的研究成果，探讨影响胃肠间质瘤恶性程度的相关因素，并通过回顾近年来的相关文献，提出对临床实践的启示与未来研究的方向，从而为GISTs的早期诊断和个性化治疗提供理论依据。Gastrointestinal stromal tumors (GISTs) are rare neoplasms originating from the digestive tract, and their malignant potential significantly impacts patient prognosis and treatment strategies. In recent years, with advances in molecular biology and oncology, researchers have increasingly recognized that multiple factors play crucial roles in determining the malignancy of GISTs, including genetic mutations, tumor size, and histological characteristics. However, current understanding of the precise mechanisms and interrelationships of these factors in GIST malignancy remains controversial and incomplete. This article aims to comprehensively analyze existing research findings, explore the factors influencing the malignant potential of GISTs, and review recent relevant literature to provide insights for clinical practice and future research directions. The ultimate goal is to establish a theoretical foundation for the early diagnosis and personalized treatment of GISTs.
Source: Advances in Clinical Medicine
Author: 欣彤 刘
Language: English
Subfield: Gastroenterology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W4411431491