Work

Higher dietary insulinemic potential is associated with kidney stones: a nationally representative cross-sectional study

Year: 2025

Type: article

Abstract: BACKGROUND: Insulin response may significantly contribute to the formation of kidney stones. Diets can modulate the insulin response and we hypothesize that high insulinemic potential diets may increase the kidney stones risk. METHODS: Data were from the US National Health and Nutrition Examination Survey. Diets were assessed by 24-hour dietary recall. Two empirical dietary indices for insulin resistance (EDIR) and hyperinsulinemia (EDIH) were used to reflect the dietary insulinemic potential. Diagnosis of kidney stones was based on self-report. Logistic regression was employed to calculate ORs and 95% CIs while adjusting for variables identified through a directed acyclic graph (DAG). RESULTS: = 0.001] scores were both positively associated with kidney stones. The conclusion remains unchanged in the sensitivity analysis after adjusting for potential mediating factors that were identified from the DAG, including BMI, hypertension, and diabetes. Subgroup analysis showed that results in most subgroups were consistent with the main analysis. CONCLUSIONS: This study indicates that the insulinemic potential of diet may partly underlie the influence of dietary patterns on kidney stones, emphasizing the importance of avoiding dietary patterns with insulinemic potential. CLINICAL TRIAL NUMBER: Not applicable.

Source: Nutrition Journal

DOI: 10.1186/s12937-025-01163-z

Authors: Bao Zhang, Mengsha Tang, Xiude Li

Institutions: First Affiliated Hospital of Anhui Medical University, Wannan Medical College, Anhui Medical University

Language: English

Topic: Kidney Stones and Urolithiasis Treatments

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,190