Segmented milli-fluidic crystallisation of paracetamol with in situ single-crystal X-ray diffraction
Year: 2025
Type: article
Abstract: single-crystal X-ray diffraction has been achieved on a series of growing singular crystals through the use of segmented flow cooling crystallisation, holding crystals in an X-ray beam for 4.2 s whilst they freely rotate whilst flowing inside tubing. Upon triggering of a passing slug at the analysis point, the tubing is moved in the opposite direction to the flow, enabling the crystal to remain within the X-ray beam whilst maintaining the free rotation of the crystal due to fluid movement. Structure solution of paracetamol form I has been achieved with 0.8 Å resolution using data combined from 13 crystals whilst unit cell information can be extracted from a single crystal.
Source: Chemical Science
DOI: 10.1039/d4sc08565e
Language: English
Subfield: Materials Chemistry
Field: Materials Science
Domain: Physical Sciences
Open Access status: diamond
Awards: G2127451590, Applying Long-lived Metastable States with Switchable Functionality via Kinetic Control of Molecular Assembly - a Programme in Functional Materials, EPSRC Centre for Doctoral Training in Sustainable Chemical Technologies, G3649392433, Future Continuous Manufacturing and Advanced Crystallisation Research Hub, G5043768423, G5440326398, G5843925129, G6251510095
OpenAlex ID: W4411436434