Combating oral biofilms in Nigerian schoolchildren: a synergistic approach using Macrosphyra longistyla extracts and titanium-ferrite nanoparticles
Year: 2025
Type: article
Abstract: Introduction: The burden of infectious and non-infectious debilitating diseases of oral etiology is common in developing countries. The pathogenicity of oral infectious diseases is believed to be exacerbated by the uncontrolled progression of biofilm-producing bacteria. In contemporary research endeavours, there is a proposition to utilize anti-infective compounds in the control of biofilm-induced infections. This research was carried out to isolate and control biofilm-producing bacteria using anti-infective nanoparticles and a plant extract. Methods: plant extracts. Bioactive antimicrobials were analyzed by Fourier-transform Infrared (FTIR) spectroscopy. The surface morphology was determined using a scanning electron microscope (SEM), and toxicological properties were characterized on adult Wistar rats. Results: doped with TF nanoparticles (MSLNP) is a complex compound that contains a variety of different chemical groups. Histology revealed no significant derangements observed in the histoarchitecture of experimental groups. This suggests that the compound shows potential as antimicrobial therapy in battling bacterial oral biofilms. It is recommended that the compound undergo further testing in the drug design process.
Source: PubMed
DOI: 10.3205/dgkh000551
Authors: Nwankwo, Chukwuemeka E., Osho, Adeleke, Adewuy, Adewale, Otuechere, Chiagoziem, Olawoye, Idowu B., Fayemi, Scott O., Oguzie, Judith U., Uwanibe, Jessica, Adesina, Adedotun F., Durugbo, Ernest U., Adedokun, Oluwatobi, Ajisegiri, Damilola, Akinlawon, Ladimeji, Eromon, Philomena, Folarin, Onikepe, Happi, Christian
Institutions: Redeemer's University, Western University, Caleb University
Language: English
Subfield: Materials Chemistry
Field: Materials Science
Domain: Physical Sciences
Open Access status: green
OpenAlex ID: W4411436609