Work

Dual role of microglia in glaucoma: Regulation of neuroinflammation and neuroregeneration

Year: 2025

Type: article

Abstract: Globally, glaucoma stands as a primary cause of irreversible blindness, marked by intricate pathophysiological processes in which neuroinflammation plays a pivotal role. As the principal immune cells within the central nervous system, microglia play a dual function in the progression of glaucoma. Under standard physiological states, microglia safeguard the retina by offering neurotrophic support and removing cellular debris. In the pathological progression of glaucoma, microglia become activated and release significant levels of inflammatory factors, resulting in retinal ganglion cell injury, cell death, and impaired neuroregeneration. This review focuses on examining the dual functions of microglia in glaucoma, evaluating their influence on retinal neurodegeneration and repair, and suggesting that modulating microglial activity could serve as a promising therapeutic strategy. Understanding the mechanisms of microglial action in glaucoma is crucial for unveiling the complex pathophysiological processes of the disease and developing new therapeutic strategies.

Source: Neural Regeneration Research

DOI: 10.4103/nrr.nrr-d-24-00876

Authors: Panpan Li, Xin Shi, Verena Prokosch

Institutions: University of Cologne, Yunnan University, University Hospital Cologne, Kunming University of Science and Technology, First People's Hospital of Yunnan Province

Language: English

Topic: Glaucoma and retinal disorders

Subfield: Ophthalmology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,500