Work

Prognostic value of RS1333040 polymorphism in the ANRIL gene for coronary artery lesions and cardiovascular events in acute myocardial infarction patients

Year: 2025

Type: article

Abstract: Background: polymorphism shows potential association with coronary artery lesions and cardiovascular events in AMI patients, though data remains limited. Objectives: gene polymorphism for coronary artery lesions and cardiovascular events in AMI patients. Materials and methods: A cross-sectional descriptive study with longitudinal follow-up, conducted at the Interventional Cardiology Department of Can Tho Central General Hospital from October 2022 to June 2024. AMI patients underwent clinical examination, genetic sequencing, and cardiovascular event monitoring. Results: Among 150 patients (mean age 63.8 ± 10.3 years, 70.7 % male), genotype distribution showed TT as the most prevalent (55.3 %), TC (38.7 %), and CC (6.0 %). Diabetes mellitus was more prevalent in the TT genotype (28.9 %) versus TC (12.1 %) and CC (11.1 %). Severe coronary artery lesions were more common in TT genotype patients (65.7 % vs. 45.4 %; p < 0.05), with the T allele identified as a risk allele (OR = 2.22; 95 % CI: 1.29-3.81; p < 0.05). Multi-vessel coronary artery disease (CAD) was also more frequent in TT genotype patients (59.8 % vs. 49.2 %; p < 0.05). At the 9-month follow-up, event rates were: mortality 4.0 %, stroke 0.7 %, HF hospitalization 6.0 %, and MACE 10.7 %. Independent predictors for MACE initiation included age (HR = 1.05), diabetes (HR = 2.98), TT genotype (HR = 3.63), and T allele (HR = 3.39). Conclusion: gene show more severe coronary lesions, higher multi-vessel disease risk, and poorer prognosis with increased MACE event probability.

Source: International Journal of Cardiology Cardiovascular Risk and Prevention

DOI: 10.1016/j.ijcrp.2025.200458