Work

Neck circumference predicts the incident cardiac events of obese hypertension with obstructive sleep apnea

Year: 2025

Type: article

Abstract: Background Elevated NC has been indicated as a risk factor for hypertensive with obstructive sleep apnea (OSA) in our previous cross-sectional study, but limited data are available regarding the prognostic value of elevated NC and cardiovascular outcome(CVD) in Chinese hypertensives with OSA. Methods This study included hospitalized hypertensive patients with recorded NC measurements at baseline (2011–2013) by using the data from a large retrospective cohort study (UROSAH Study). Baseline characteristics of the included participants were summarized by the median of NC. The cumulative incidence of cardiac event (CVE) was calculated and the Cox proportional hazards with stepwise models were performed to evaluate the association between NC and CVE. Results Overall, 3082 participants were categorized into 2 groups according to the median of the baseline NC defined as ≤40cm (N=1691) and >40cm (N=1391). During a median follow-up of 7.0 years, 211 new-onset CVE occurred. In total cohort, NC>40cm was associated with a higher risk of new-onset CVE after adjusted confounders [hazard ratio (HR), 1.39, 95% confidence interval(CI), 1.01-1.93, P =0.044]. In subgroup analyses, the similar results were observed in patients with age≥60years, OSA, obesity (BMI≥28kg/m 2 ), non-smokers, and eGFR≤90ml/min·1.73m 2 . Sensitivity analysis showed same result in patients who were not treated with regular CPAP. Conclusion NC > 40cm may provide prognostic information for cardiovascular events in hypertensive patients, especially for obese patients and individuals with OSA, suggesting NC >40cm should be promoted in the risk evaluation of CVD, but the potential mechanism need to explore further.

Source: American Journal of Preventive Cardiology

DOI: 10.1016/j.ajpc.2025.101048

Authors: Xiaoguang Yao, Keming Zhou, Wen Jiang, Mulalibieke Heizhati, Subijiang Tuerxun, Lei Wang

Institution: People's Hospital of Xinjiang Uygur Autonomous Region

Language: English

Topic: Obstructive Sleep Apnea Research

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,900