Work

Adaptive Repeat Quad Shot Radiation Therapy for Uncontrolled Symptomatic Fungating or Skin-Infiltrating Primary and Regional Nodes in Patients with Metastatic Breast Cancer: Durable In-Field Tumor Control Without Interrupting Systemic Therapy

Year: 2025

Type: article

Abstract: About 20-30% of women with Stage I-III breast cancer (BC) eventually develop metastasis (recurrent mBC: re-mBC), and nearly 6% of new patients present mBC at initial diagnosis (de novo mBC: dn-mBC).1-3 For patients with mBC, systemic therapies (ST: cytotoxic chemotherapy, endocrine therapy, targeted therapy, and immunotherapy) are the primary treatment with consideration of locoregional symptoms intervention. Timely initiation and adherence to ST schedules are essential components of effective treatment.

Source: Advances in Radiation Oncology

DOI: 10.1016/j.adro.2025.101842

Authors: Whoon Jong Kil, Wyatt Smith, Eugene Muchnik, Ryan Collins, David Cousins

Institutions: University of Pittsburgh, UPMC Hillman Cancer Center, University of Pittsburgh Medical Center

Language: English

Topic: Breast Cancer Treatment Studies

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,500