Work

Solid-state nanopore quantification of discrete sequence motifs from DNA and RNA targets in human plasma

Year: 2025

Type: article

Abstract: resistive pulse sensing. We first demonstrate our approach on single-strand DNA and single-strand RNA spiked into human plasma and then extend the methodology to double-strand DNA, expanding the range of motifs that can be targeted. These advancements position our assay as a tool for the analysis of viral, bacterial, and human genetic markers.

Source: The Analyst

DOI: 10.1039/d5an00373c

Authors: Mohamed Amin Elaguech, Komal Sethi, Adam R. Hall

Institutions: Virginia Tech - Wake Forest University School of Biomedical Engineering & Sciences, Wake Forest University, Virginia Tech, Wake Forest Baptist Comprehensive Cancer Center, Wake Forest University Health Sciences

Language: English

Topic: Nanopore and Nanochannel Transport Studies

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

Open Access status: hybrid

Funders: National Institutes of Health, National Cancer Institute

Awards: G1754746851, G2234538817, Detecting diverse nucleic acid biomarkers of cancer with solid-state nanopores