A Study on Comparison of Management of Recurrent seizure among Epileptic patient in a Government Medical College Hospital
Year: 2025
Type: article
Study design: Observational Study
Abstract: Introduction: Epilepsy is a chronic neurological illness that causes frequent, unprovoked seizures. Even with significant progress in our knowledge of the pathophysiology of epilepsy and the availability of a wide variety of antiepileptic medicines (AEDs), many patients still find it difficult to achieve adequate seizure control. There is still a lack of high-quality prospective observational studies that comprehensively compare the efficacy, safety, and tolerability of various management regimens for recurrent seizures among epileptic patients, despite the availability of a wide range of therapeutic alternatives. By offering insightful information on treatment patterns, clinical outcomes, and factors influencing treatment decisions across a variety of patient populations, these studies play a critical role in bridging the gap between clinical research and actual clinical practice. Methods and Material: This was a prospective observational study conducted on 240 patients who were admitted with recurrent seizure disorder (drug withdrawal seizure disorder) in the Department of General Medicine at Tiruppur Medical College Hospital over a period of 6 months, following and satisfying the inclusion and exclusion criteria Results: There were 57 females (24%) and 183 males (76%) in the study population. The patients' ages were distributed as follows: 50 (21%) belonged to the 18–30 age group, 102 (42%) to the 31–45 age group, and 88 (37%) to the 46–65 age group. 32% of the study's patients were smokers, 4% were drinkers, and 9% said they smoked and drank. Most people (55%) didn't follow these routines. Seventy percent of the patients had generalised tonic-clonic seizures. Of the 240 patients, 65 (or 27%) reported missing doses, 110 (or 46%) showed inconsistent drug intake, and 65 (or 27%) had stopped taking their prescription entirely. The study showed a variety of pharmaceutical choices with sodium valproate being administered the most (20%), followed by carbamazepine (10%) and levetiracetam (18%). According to the study, 74% of instances were caused by drug withdrawal seizures, with breakthrough seizures accounting for 19% of cases and alcohol withdrawal seizures accounting for 7%. After discharge Seizures: Within a month following release, 96% of patients continued to be seizure-free. After treatment, 80.8 percent of patients were able to manage their seizures in 2 to 4 days, whereas 9.5% of patients needed 5 days to gain control. Conclusion: The study emphasised the value of individualised care for a range of age groups, the influence of lifestyle factors on the control of seizures, and the efficacy of phenytoin in the management of generalised seizures. Critical difficulties were managing withdrawal symptoms and adhering to medication regimens. The results of the study highlight the necessity of post-hospitalization care and customised treatment plans. Furthermore, the variety of prescription options and drug combinations provides guidance for medical professionals. This study adds to the continuing endeavour to better the treatment of epilepsy and, eventually, patient outcomes. Keywords: Epielepsy, Medication adherence, phenytoin, levetiracetam, missed dose.
Authors: Dr. Megala Kesavan, Dr. Hirija R.A, Dr. D.G. Dino Stalin, Dr. Ajo A. U, Dr. Krishna Kumar D, Dr. Boopathi Raja
Institution: Tamil Nadu Dr. M.G.R. Medical University
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4411452711