Work

Fucoidan and Hyaluronic Acid Modified ZE21B Magnesium Alloy for Better Hemocompatibility and Vascular Cell Response

Year: 2025

Type: article

Abstract: Magnesium alloy stents have great potential for the treatment of cardiovascular and cerebrovascular diseases due to their excellent mechanical supportability and biodegradability. However, bare magnesium alloy stents often degrade too rapidly and demonstrate insufficient biocompatibility, severely limiting their clinical applicability. Herein, a composite coating consisting of MgF2 conversion layer, polydopamine (PDA) layer, fucoidan, and hyaluronic acid was prepared to enhance the corrosion resistance and biocompatibility of ZE21B alloy for vascular stent application. The modified ZE21B alloy exhibited relatively high surface roughness, moderate wettability, and better corrosion resistance. Moreover, the modified ZE21B alloy with low hemolysis rate and fibrinogen adsorption level confirmed improved hemocompatibility for medical requirements. Furthermore, the ZE21B alloy modified with fucoidan and hyaluronic acid could promote the adhesion, proliferation, and NO release of ECs, and meanwhile inhibit the adhesion and proliferation of SMCs and promote the competitive growth of ECs over SMCs due to the synergistic effect of natural fucoidan and hyaluronic acid. The modification with fucoidan and hyaluronic acid significantly enhanced the corrosion resistance and biocompatibility of ZE21B magnesium alloy, thereby providing a simple and effective strategies for the development of biodegradable vascular stents.

Source: Coatings

DOI: 10.3390/coatings15060732

Authors: Haoran Wang, Yunwei Gu, Qi Wang, Lingchuang Bai, Shaokang Guan

Institution: Zhengzhou University

Language: English

Topic: Magnesium Alloys: Properties and Applications

Subfield: Biomaterials

Field: Materials Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,137