Work

Glycosidase-activated prodrugs of a cytotoxic iron chelator for targeted cancer therapy

Year: 2025

Type: article

Abstract: New glycoside-conjugated prodrugs based on the iron chelator deferasirox were designed and their selective cleavage by glycosidases as well as cancer cell line-specific toxicity was demonstrated.

Source: RSC Medicinal Chemistry

DOI: 10.1039/d5md00232j

Authors: Debashish Tomar, Axel Steinbrueck, Adam C. Sedgwick, Matthew S. Levine, Jonathan L. Sessler, Nils Metzler-Nolte

Institutions: Ruhr University Bochum, The University of Texas at Austin, King's College London

Language: English

Topic: Nanoparticle-Based Drug Delivery

Subfield: Biomaterials

Field: Materials Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: Welch Foundation, King’s College London, King's College London, Deutsche Forschungsgemeinschaft

Awards: G1496771134, Entwicklung von Sonden für das selektive Anfärben intrazellulärer Organelle in der Röntgenfluoreszenzspektroskopie von menschlichen Zell und Gewebeproben, G19982455, G613555622, G6199215951

OpenAlex ID: W4411459277

FWCI: 0.188

Cites: 39

Cited by: 1

Related to: 10