Pre-hyperuricemia: The silent precursor to metabolic disorders
Year: 2025
Type: article
Abstract: The global prevalence of hyperuricemia has been rapidly increasing over the past two decades, primarily due to changes in dietary habits and lifestyle. Recent research has unveiled a strong association between hyperuricemia and various non-communicable diseases, suggesting that uric acid-induced systemic inflammation and endothelial dysfunction may begin even before reaching the current diagnostic threshold for hyperuricemia. This review introduces the concept of “pre-hyperuricemia,” defined as a high normal serum uric acid level, and explores its potential role as an early indicator and risk factor for metabolic disorders. We have discussed the molecular mechanisms underlying uric acid-induced inflammation, the epidemiology of hyperuricemia, and its associations with various extra-articular diseases. Furthermore, we have emphasized the importance of early detection and management of pre-hyperuricemia through lifestyle modifications to prevent the development and progression of uric acid-related diseases.
Source: Medicine India
Authors: Rahul Garg, Prashant Prakash
Institution: Sarojini Naidu Medical College
Language: English
Subfield: Nephrology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W4411460949