Sustainable Utilization of Agricultural By-Products: in vivo investigation of the antidiarrheal potential of Litchi chinensis seed extract
Year: 2025
Type: article
Abstract: Objectives: seed extract (LCSE). Methods: seeds. Acute oral toxicity was conducted by administering a single 2,000 mg/kg dose to female Swiss albino mice. Mice were divided into five groups (control, positive control with Loperamide, and test groups receiving 100, 200, and 400 mg/kg of LCSE) for the antidiarrheal assay. Diarrhea was induced with castor oil, and parameters such as onset of diarrhea, fecal output, gastrointestinal motility, and enteropooling were measured. The statistical analysis was conducted in GraphPad Prism version 10.1.2 using one-way ANOVA followed by a Dunnett multiple comparison test. Results: antidiarrheal index (ADI) showed a dose-dependent increase, with the highest ADI recorded at 400 mg/kg (189.42%), slightly surpassing the standard drug, loperamide (160.14%). Conclusion: The finding supports the antidiarrheal potential of LCSE holds potent antidiarrheal properties, positioning it as a promising, sustainable alternative to modern medications.
Source: Journal of pharmacopuncture
Authors: Mustakin Ahmed Shohel, Md. Humayan Kabir, Ivvala AnShaker, Sumaiya Siddika, Sheikh Arafat Rahman, Sumaiya Siddiquea, Nirmal Chandra Mahat, Tarique Muhammad Tawabul Islam, Md. Abul Kashem Tang
Institutions: Parul University, Islamic University
Language: English
Topic: Medicinal Plant Research
Subfield: Plant Science
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W4411462156