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Association of Korean Medicine and polypharmacy with fall risk and mortality in older adults with stroke

Year: 2025

Type: article

Abstract: Background: Stroke survivors often take multiple medications (polypharmacy), raising concerns about falls and mortality in older adults. This study investigated whether Korean Medicine (KM)-primarily acupuncture-is associated with fall risk and mortality among older adults with stroke and polypharmacy. Methods: A population-based retrospective cohort study using South Korea's National Health Insurance Service (NHIS) claims database. Adults aged 65 or older with a first stroke in 2015 were included if they had five or more prescribed medications (polypharmacy) or ten or more (hyper-polypharmacy) for at least 270 days. KM users received acupuncture or electroacupuncture (≥3 outpatient visits or ≥1 inpatient stay) within a year of stroke onset. The primary outcome was falls resulting in fracture; the secondary outcome was all-cause mortality-both assessed over 3 years. Propensity score matching balanced demographics, comorbidities, and medication use. Cox proportional hazards and subgroup analyses were conducted. Subgroup and sensitivity analyses explored effect modification. Results: Among 25,034 older stroke patients, 10,011 had polypharmacy; of those, 6,809 used KM. After matching, 3,127 KM users were compared with 3,127 non-users. KM users with polypharmacy had a higher rate of falls but lower all-cause mortality than non-users. In hyper-polypharmacy, KM use did not significantly affect falls but was associated with lower mortality. Sensitivity analyses of the unmatched cohort, alternative outcome definitions, and interactions yielded consistent patterns. Conclusion: In older adults with stroke and polypharmacy, KM may improve functional recovery and mobility, potentially increasing falls if balance training is inadequate, yet simultaneously confer survival advantages-perhaps through neuro-immune or systemic effects-irrespective of medication load. Among the more frail hyper-polypharmacy group, KM reduced mortality without altering falls, suggesting that functional gains and competing-risk dynamics differ by medication intensity. Prospective studies with granular functional measures, drug-drug interaction data, and formal competing-risk models are needed to optimize the safe integration of KM into comprehensive stroke care.

Source: Frontiers in Pharmacology

DOI: 10.3389/fphar.2025.1621819

Authors: Ye-Seul Lee, Bo-Hyoung Jang, Jin Pyeong Jeon, Han-Gyul Lee, Seungwon Kwon, Woo-Sang Jung