Work

Association between dietary multi-metal intake and the risk of diabetic retinopathy: a population-based study

Year: 2025

Type: article

Abstract: Objective To investigate the association between dietary metals intake and the risk of diabetic retinopathy (DR) in adults with diabetes. Methods Data from 2,822 U. S. adults with diabetes in National Health and Nutrition Examination Survey (NHANES) 2007–2016 were analyzed. Associations between the intake of six dietary metals and DR risk were assessed using multivariable logistic regression, Weighted Quantile Sum (WQS) regression, and Bayesian Kernel Machine Regression (BKMR). Restricted Cubic Spline (RCS) regression examined the dose–response relationship between intake of dietary metal and DR risk. Mediation analysis explored the underlying mechanisms. Results Log10-transformed dietary Zinc (Zn) (OR = 0.53, 95% CI 0.35–0.80, p = 0.003) were negatively associated with the DR risk. WQS regression indicated that the combined effects of dietary metals intake were negatively associated with the risk of DR (OR = 0.79, 95% CI 0.61–0.97, p = 0.024), with Zn contributing the most to the reduced risk (36.4%). BKMR model suggested the negative association between the combined intake of 6 metals and DR risk, with Zn receiving the highest posterior inclusion probability (PIP) (0.8574). Conclusion In American adults with diabetes, elevated dietary metals intake, especially zinc, may be associated with a lower risk of DR.

Source: Frontiers in Nutrition

DOI: 10.3389/fnut.2025.1595788

Authors: Chaohua Zhang, Haiyang Peng, Qin Lang, Haoyu Fang, Keqin Zhang, Andong Zhao

Institutions: Second Affiliated Hospital of Chongqing Medical University, Chongqing Medical University

Language: English

Topic: Trace Elements in Health

Subfield: Nutrition and Dietetics

Field: Nursing

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,801