Work

Cellular wound healing: A two-step mechanism of plasma membrane repair by annexins and calpains

Year: 2025

Type: article

Abstract: In this issue, Williams et al. (https://doi.org/10.1083/jcb.202408159) reveal a two-step plasma membrane repair process upon injury: annexins first stabilize damage sites, then calcium-activated calpains cleave these patches, triggering microvesicle shedding-mirroring the clot-and-scab resolution seen in tissue-level wound healing.

Source: The Journal of Cell Biology

DOI: 10.1083/jcb.202505027

Authors: Sabina Elmi, Jesper Nylandsted

Institution: University of Southern Denmark

Language: English

Topic: S100 Proteins and Annexins

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W4411469193