Targeted Delivery of α‐ketoglutarate to Macrophages in Bone: A Novel Therapeutic Strategy for Improving Fracture Healing in Type 2 Diabetes (Adv. Sci. 23/2025)
Year: 2025
Type: article
Abstract: Improving Fracture Healing in Type 2 Diabetes In article number 2415667, Jia Li, Wei Lei, Yafei Feng, and co-workers demonstrate that diminished α-ketoglutarate (α-KG) levels impair bone morphogenetic protein 2 (BMP2) secretion in macrophages under type 2 diabetes mellitus (T2DM) conditions. This cover illustration depicts the mechanism of alendronate-modified liposomes designed to specifically target macrophages and deliver α-KG payloads. Through epigenetic reprogramming mediated by α-KG supplementation, macrophages regain their ability to secrete BMP2, thereby promoting fracture healing processes. These findings establish targeted α-KG delivery to macrophages as a novel therapeutic strategy for improving impaired fracture healing in T2DM patients.
Source: Advanced Science
Authors: Jing Wang, Jiahao Cao, Siqi Zhang, Hongli Chen, Xuebing Yu, Xinli Wang, Tianji Wang, Wei Cao, Wengang Dong, Xinsen Lin, Jia Li, Wei Lei, Yafei Feng
Language: English
Topic: Bone Metabolism and Diseases
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $6,730
OpenAlex ID: W4411494118