Work

Selenium-Substituted BOIMPY for Enhanced Photodynamic Therapy

Year: 2025

Type: article

Abstract: Seleno-substituted bis-(boron difluoride)-8-imidazo-dipyrro-methene (BOIMPY) derivatives displayed improved photophysical features over twisted-BOIMPY, such as greater Stokes shifts, while compromising radiative relaxation and intersystem crossing, making them suitable for imaging-guided photodynamic therapy (PDT). One exhibited improved Type I and Type II PDT against cancer cells when activated by near-infrared light. Its potential as a targeted PDT agent for cancer treatment is demonstrated by its remarkable phototoxicity in the nanomolar range and minimal dark toxicity.

Source: ACS Medicinal Chemistry Letters

DOI: 10.1021/acsmedchemlett.5c00174

Authors: Sorachat Tharamak, Bongkot Ouengwanarat, Tunyawat Khrootkaew, Prapassara Muangsopa, Kantapat Chansaenpak, Kenika Khotchasanthong, Kittipong Chainok, Kevin Burgess, Anyanee Kamkaew

Institutions: Kasetsart University, Suranaree University of Technology, National Science and Technology Development Agency, National Nanotechnology Center, Thailand Science Park, Thammasat University, Texas A&M University

Language: English

Topic: Photodynamic Therapy Research Studies

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,500

Funders: Welch Foundation, Suranaree University of Technology, Kasetsart University, National Research Council of Thailand, Thailand Science Research and Innovation, National Institutes of Health, National Institute of Neurological Disorders and Stroke

Awards: G1545065402, G1744777779, G2001598591, G3743324013, G6854122815, G8072684625, G9000087021

OpenAlex ID: W4411495135

FWCI: 3.645

Cites: 29

Cited by: 6

Related to: 10