Work

Natural Plant-Based Rejuvenating Compositions: Human Study on Astragalus membranaceus and Centella asiatica Saponins for Skin Health

Year: 2025

Type: article

Study designs: Randomized Controlled Trial, Clinical Trial

Abstract: This study aimed to evaluate the effects of a proprietary plant-based formulation of Astragalus membranaceus and Centella asiatica saponins (ACS) on skin health, as both a cosmetic ingredient and a functional supplement. In this randomized, double-blind, placebo-controlled trial, 150 healthy adults were assigned to groups using topical ACS cream, oral ACS capsules, combined treatments, or corresponding placebos. Skin brightness, moisture, elasticity, melanin value, pore count, texture, and collagen content were assessed over 4 to 12 weeks. After 4 weeks of topical ACS application, skin brightness improved by 2.5%, elasticity by 6.5%, melanin decreased by 5.2%, pores reduced by 10.6%, and collagen increased by 8.7% (p < 0.05). After 12 weeks of oral ACS, brightness, elasticity, texture, and collagen significantly improved (p < 0.05). The combined treatment group showed the greatest improvements, including a 4.2% increase in brightness, 12.9% increase in moisture, 9.0% elasticity increase, and a 28.5% reduction in pore count (p < 0.05). ACS, whether used topically, orally, or in combination, effectively enhances skin health and offers a natural solution for skin rejuvenation.

Source: Cosmetics

DOI: 10.3390/cosmetics12040131

Authors: Leong-Perng Chan, Chia-Hua Liang

Institutions: Kaohsiung Medical University, Kaohsiung Medical University Chung-Ho Memorial Hospital, Chia Nan University of Pharmacy and Science

Language: English

Topic: Skin Protection and Aging

Subfield: Dermatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,172