Visible-light-mediated late-stage N-functionalization of unprotected peptides: introducing the aza-Zimmerman–O'Connell–Griffin reaction
Year: 2025
Type: article
Abstract: A sustainable, reagent-free method for amide synthesis and peptide functionalization via photoinduced ZOG rearrangement. High-yielding, purification without chromatography, and driven solely by light—ideal for greener peptide modification.
Source: Green Chemistry
DOI: 10.1039/d5gc02108a
Authors: Sara Bacaicoa, Mario Martos, Wilma Yhlen Graf, August Runemark, Ganesh H. Shinde, Ganesh S. Ghotekar, Henrik Sundén
Institution: University of Gothenburg
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: hybrid
Award: G458584355
OpenAlex ID: W4411498286