The Interplay Between Suicidal Behavior and Mental Disorders: Focusing on the Role of Glial Cells
Year: 2025
Type: article
Abstract: Glial cells have shown to possess vital and surprising roles in the brain rather than just being silent supportive cells to neurons. Different glial populations of the central nervous system in involved brain regions play various functions, express different proteins and result in fluctuating effects when altered. Glial cells pathologies were detected in most mental disorders including suicidal behavior. Suicidal behavior represents a health problem of high importance worldwide where protective measures are required to be taken at many levels. Studies on patients with mental disorders that represent risk factors for suicidal behavior, revealed multiple changes in the glia at diverse levels including variations regarding the expressed glial markers. This review summarizes the role of glia in some psychiatric disorders and highlights the crosslink between changes at the level of glial cells and development of suicidal behavior in patients with an underlying psychiatric condition; In addition, the interplay and interconnection between suicidal behavior and other mental diseases will spot the light on the routes of personalized therapy involving glial-related drugs.
Source: Neuroglia
Author: Maya Nahi Abou Chahla
Institutions: Beirut Arab University, Lebanese International University
Language: English
Subfield: Clinical Psychology
Field: Psychology
Domain: Social Sciences
Open Access status: gold
Estimated APC paid: $1,207
OpenAlex ID: W4411498722