Oxidative Stress-Induced ADAR1/2 Dysfunction Promotes Hepatocellular Carcinoma Cell Damage via Redox Imbalance
Year: 2025
Type: article
Abstract: Hepatocellular Carcinoma (HCC) progression is tightly linked to oxidative stress, yet the role of RNA Adenosine Deaminases (ADARs) in this process remains unclear. Here, we demonstrate that hydrogen peroxide (H₂O₂)-induced oxidative stress downregulates ADAR1/2 expression in HCC cells, leading to reduced A-to-I RNA editing and exacerbated cell damage. Mechanistically, ADAR loss impaired antioxidant defense by dysregulating SOD2/CAT expression and disrupting Nrf2 signaling. Our findings establish ADARs as critical regulators of redox homeostasis in HCC, offering novel therapeutic opportunities..
Author: Changquan Li
Institution: Anhui Medical University
Language: English
Topic: RNA regulation and disease
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: hybrid
OpenAlex ID: W4411499787