Year: 2025
Type: article
Abstract: Gastric cancer remains a significant global health burden, characterized by high heterogeneity. The Cancer Genome Atlas (TCGA) has been pivotal in classifying gastric cancer into distinct molecular subtypes, providing profound insights into its pathogenesis, prognosis, and potential therapeutic strategies. This review comprehensively explores the four TCGA - defined subtypes of gastric cancer: Epstein - Barr Virus (EBV) - positive, Microsatellite unstable (MSI), Genomically Stable (GS), and Chromosomally Unstable (CIN). By dissecting the unique molecular, genetic, and clinical features of each subtype, we aim to elucidate how this classification can enhance our understanding of gastric cancer and drive the development of more personalized treatment approaches.
Author: Changquan li
Institution: Anhui Medical University
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W4411499794