Work

Co-catalyzed sp3-sp3 coupling enabled by hydrofunctionalization of alkenes with nucleophiles

Year: 2025

Type: article

Abstract: Complementary to classical transition-metal-catalyzed cross-coupling reactions, transition-metal-catalyzed hydrofunctionalization of alkenes has emerged as a powerful strategy for direct and rapid construction of sp 3 - sp 3 linkages. Among various metals, cobalt has been widely used as a catalyst in the hydrofunctionalization of alkenes, demonstrating versatile catalytic reactivity for both electrophiles and nucleophiles to forge sp 3 - sp 3 bonds. When employing nucleophiles as coupling partners, the hydrofunctionalization reactions usually requires the addition of oxidants, due to the presence of nucleophilic intermediate generated through cobalt-hydride-mediated hydrogen atom transfer (HAT) with alkenes. Cobalt-catalyzed hydrofunctionalizations of alkenes with nucleophiles represent an interesting and emerging strategy due to the use of both reductant and oxidant. This review summarizes the recent development of Co-catalyzed hydrofunctionalization of alkenes with nucleophiles, focusing on the construction of various C( sp 3 )-X( sp 3 ) bonds (X = N, O, S, F). Future direction of this strategy to broaden the scope of sp 3 - sp 3 bond formation is also discussed.

Source: Tetrahedron Chem

DOI: 10.1016/j.tchem.2025.100142

Authors: Li-Xia Liu, Muneer-ul-Shafi Bhat, Yu-Long Li, Wei Shu

Institutions: Southern University of Science and Technology, Sichuan University of Science and Engineering, Nankai University

Language: English

Topic: Catalytic Cross-Coupling Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $2,660