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Potential Strategies for Reducing Mortality and Morbidity in Acute Ischemic Cardiogenic Shock

Year: 2025

Type: article

Abstract: Cardiogenic shock is predominantly caused by acute ischemic myocardial injury. Despite advancements in reperfusion strategies, outcomes remain poor, with the duration of ischemia before reperfusion playing a crucial role in the development of irreversible damage. This review synthesizes insights from animal models and human studies, highlighting the limited myocardial salvage beyond 90 minutes of ischemia. In light of the high mortality rates associated with cardiogenic shock, this review proposes re-evaluating pre-hospital fibrinolysis, exploring left ventricular unloading strategies before reperfusion, and assessing the potential role of endothelin antagonists. These approaches aim to improve outcomes in this high-risk population.

Source: Journal of shock & hemodynamics

DOI: 10.58464/2836-0605.1059

Authors: Richard Smalling, James McCarthy, Tim Henry, Ali Denktas

Institutions: Memorial Hermann, Memorial Hermann–Texas Medical Center, The University of Texas Health Science Center at Houston, Christ Hospital, Christ Hospital, Baylor College of Medicine

Language: English

Topic: Mechanical Circulatory Support Devices

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W4411507697

FWCI:

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