Evaluation of Serum IL-10, TNF-α and Albumin Levels among Male Type 2 Diabetes Mellitus Patients in a Tertiary Hospital in Nigeria
Year: 2025
Type: article
Study design: Observational Study
Abstract: Type 2 diabetes (T2DM) is associated with a chronic inflammatory state and a disturbance in cytokine balance. This study aimed to evaluate the levels of TNF-α, IL-10, and albumin in the serum of males with type 2 diabetes compared to healthy individuals. A case-control study was conducted involving 60 participants (30 patients and 30 healthy individuals), and the samples were analyzed using ELISA techniques and the BCG method. The results showed a significant increase in TNF-α (53.97 ± 10.22 Vs 15.11 ± 2.82) and IL-10 (17.07 ± 1.42 Vs 4.12 ± 0.88) levels among the patients (P = <0.001), with no significant difference in albumin levels (p>0.05). The results indicate the presence of a simultaneous inflammatory and anti-inflammatory response, which underscores the importance of these cytokines as biomarkers in diabetes monitoring.
Authors: Ehiaghe, F.A., Ahmed, V.U., Ehiaghe, J.I., Ogalagu, R.O., Obu, S.I., Ize-Iyamu, J. A, Osakue, O.N., Ogbodo, E.C.
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4411519709