Bioprocess Engineering: Advances in Cell Culture Systems, Reactor Design, Scale-up Strategies, and Intensification Processes for the Production of Biological and Bioactive Compounds
Year: 2025
Type: article
Abstract: Bioprocess engineering is undergoing an unprecedented transformation, driven by the growing demand for complex and bioactive biological products across diverse industries, from pharmaceuticals to food and energy. Recent advances have redefined the efficiency, scalability, and sustainability of biomanufacturing. Key elements of this evolution include the widespread adoption of single-use systems, the integration of automation and artificial intelligence (AI) for precise control and predictive optimization, and the fundamental shift toward continuous bioprocessing. These innovations not only reduce costs and production times but also improve product quality and consistency, enabling the manufacturing of personalized therapies and high-value compounds. Scaling strategies have diversified to include both scale-up and parallel expansion (scale-out), tailored to specific product needs. Together, these developments are laying the foundation for more agile, cost-effective, and environmentally responsible biomanufacturing, preparing the industry to address global challenges in health and sustainability.
Source: eVitroKhem
DOI: 10.56294/evk2025149
Authors: Freddy Ednildon Bautista-Vanegas, Jose Luis Diaz-Guerrero, Ingrid Neysa Cabezas-Soliz, Blas Apaza-Huanca, Estefannie Eunice Valverde Fernández, Jhossmar Cristians Auza-Santivañez, Themis Karim Ocampo Gamboa, Rebeca Rocio Gomez Rosales, Luis Mariano Tecuatl Gómez, Pablo Carías, Ruben Marco Antonio Soliz-Mendoza
Language: English
Topic: Fluid Dynamics and Mixing
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: hybrid
OpenAlex ID: W4411530772