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Hypoglycemic Encephalopathy in a 46-Year-Old Patient Following Sulfonylurea Overdose: A Case Report

Year: 2025

Type: article

Abstract: Hypoglycemic encephalopathy is defined by coma or altered consciousness in patients with a blood glucose level below 50 mg/dl persisting for more than 24 hours despite normalization of glucose levels, without any other obvious cause [1]. It is a rare but serious complication with a mortality rate that can reach 50%, often associated with visible structural anomalies on Magnetic resonance imaging (MRI) [2]. We report the case of a 46-year-old patient admitted to the intensive care unit for altered consciousness secondary to voluntary sulfonylurea overdose. The MRI performed on the seventh day of hospitalization revealed bilateral cortico-subcortical and basal ganglia abnormalities characteristic of hypoglycemic encephalopathy. The clinical course was marked by a progressive improvement in neurological status.

Source: SAS Journal of Medicine

DOI: 10.36347/sasjm.2025.v11i06.010

Authors: Dr. Othman Sebbata, Abdellah El Graoui, Omar Aichouni Saad Khairoun, Bouchra Armel, Rachid El Moussaoui

Institution: Centre Hospitalier Ibn Sina

Language: English

Topic: Neurological and metabolic disorders

Subfield: Endocrinology, Diabetes and Metabolism

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4411535899

FWCI:

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