Work

Involvement of the central nervous system in relapsed T-cell lymphoma: insights from four case studies

Year: 2025

Type: article

Abstract: CNS involvement in T-cell lymphoma is rare, with a 2-6 % risk of relapse. This report presents four cases of CNS relapse in aggressive T-cell lymphomas, including PTCL NOS, AITL, ALCL ALK (-), and ENKTCL. Patients experienced severe neurological symptoms, elevated CSF WBC counts, and resistance to various treatment regimens, including intrathecal HD MTX, salvage chemotherapy, and immunotherapy. Median survival was 1.5-3.5 months, highlighting the poor prognosis. The findings highlight the complexities of managing CNS relapse, the evolving understanding of prophylactic strategies, and the potential for innovative, targeted therapeutic combinations to enhance outcomes for these high-risk patients.

Source: Leukemia Research Reports

DOI: 10.1016/j.lrr.2025.100524

Authors: Radu Chiriac, Lucile Baseggio

Institutions: Hospices Civils de Lyon, Hôpital Lyon Sud

Language: English

Topic: CNS Lymphoma Diagnosis and Treatment

Subfield: Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,180