Year: 2025
Type: article
Abstract: studies, this platform demonstrated robust motion capabilities in complex human saliva and accelerated drug release kinetics. In a rabbit model, using epinephrine as the model drug, the sublingual microrobotic pill achieved significantly faster drug delivery speed, efficiency, and bioavailability compared to a conventional pill. Moreover, when compared against the gold standard intramuscular injections, the microstirring pill provides competitive delivery speed and enhanced absorption profile, demonstrating its potential for use in the treatment of conditions like anaphylactic shock. Such user-friendly, non-invasive sublingual microrobotic pills can be readily employed for delivering a wide range of drugs, offering a versatile solution for acute conditions requiring rapid therapeutic onset or when enteral absorption is not feasible.
Source: Nanoscale Advances
DOI: 10.1039/d5na00313j
Authors: Nelly Askarinam, Chuanrui Chen, Vivian Vo, Michael Casares, Kyra Wu, Ethan Shen, Majd Iskandarani, Víctor de la Asunción-Nadal, An-Yi Chang, Tomohiro Yamamoto, Janna Sofia Sage-Sepulveda, Baha Öndeş, Zhenning Zhou, Zike Yan, Jesse Qualliotine, Joseph Wang
Institutions: University of California San Diego, Moores Cancer Center
Language: English
Topic: Micro and Nano Robotics
Subfield: Condensed Matter Physics
Field: Physics and Astronomy
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $1,962
OpenAlex ID: W4411553935