Evaluation of circulating ApoL1 in diabetes mellitus patients attending Aminu Kano teaching Hospital
Year: 2025
Type: article
Study design: Observational Study
Abstract: Apolipoprotein L1 (ApoL1) was originally recognized as a component of human high-density lipoprotein (HDL) particles. Subsequent research uncovered several highly homologous apolipoprotein L proteins encoded by genes clustered at the long arm of chromosome 22 (22q12.1–13.1). Data suggests that ApoL1 may be associated with lipid and glucose metabolisms or may exert an antioxidative effect as a distinct HDL subspecies in certain dyslipidaemia subjects. The present study aimed to evaluate the circulating APOL1 in diabetes mellitus patients attending Aminu Kano teaching Hospital. Two hundred study participants were recruited out of which 100 were Type Diabetes mellitus patients and 100 were apparently healthy individuals. Fasting plasma glucose, Glycated haemoglobin, lipid profile and serum Apolipoprotein L1 were measured in the blood samples collected from each study participants. Student t- test and Pearson correlation were employed for mean comparison and correlation of the data collected respectively. Results shows significant difference in the BMI, FPG, HbA1c, Lipid Profile and APOL1 between the T2DM and the control group (p≤ 0.005). Pearson's correlation shows no significant association between APOL1 and T2DM markers (FPG and HbA1c) as well as lipid profile.
Authors: A.A. Jibril, M.Y. Gwarzo, H.L Abdullahi, N.S Babale, F. Adamu, U.M Khalid, A.H. Halliru, I.S Jamilah, A.Y Ahmed, R.I Mahmud, M.M. Usman
Institution: Aminu Kano Teaching Hospital
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4411556396