Work

Borrelia-Induced Koebner Phenomenon in Psoriasis: A Role of Local TNF-α Production?

Year: 2025

Type: article

Abstract: Psoriasis vulgaris is a chronic, immune-mediated inflammatory skin condition. Moderate to severe forms of the disease are effectively treated with biologics targeting Interleukin-(IL-)17 and tumor necrosis factor alpha (TNF-α), which are both produced by T cells, as well as dendritic cell-derived IL-23. In addition to genetic predispositions, environmental factors affect the onset and severity of symptoms [1]. The Koebner phenomenon (KP) describes the emergence of skin lesions at sites of nonspecific trauma, like scratching, tattooing, or exposure to chemical irritants, on clinically unconspicous skin [2,3]. This report discusses a Borrelia-induced KP in a psoriasis patient on ustekinumab therapy.

Source: Archives of Clinical and Medical Case Reports

DOI: 10.26502/acmcr.96550720

Authors: Lena Schulmeyer, Janik Fleißner, Simon Überschaar, Matthias Goebeler, Andreas Kerstan

Language: English

Topic: Psoriasis: Treatment and Pathogenesis

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4411560329

FWCI:

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Related to: 10