Work

Combined Multiomics Analysis Reveals the Role of ANXA1 Methylation and miRNA ‐Targeted LDLR in Polycystic Ovary Syndrome

Year: 2025

Type: article

Abstract: Purpose: Polycystic ovary syndrome (PCOS) is an endocrine syndrome that afflicts women of childbearing age, whose specific pathogenesis is unknown. Combined multiomics analysis on it is still lacking. The purpose of this study was to use combined multiomics analyses to learn about the development of PCOS. Methods: We randomly selected three PCOS mouse models and two control mice as the mouse group, as well as three PCOS patients and two normal women as the human group. The data were analyzed by multiomics analysis including methylomes, transcriptomics, and metabolomics. We explored the key genes involved in the occurrence and development of PCOS that were common in multiomics. Methylation-specific polymerase chain reaction (MSP) and real-time PCR (qPCR) experiments were performed to verify the reliability of the results. Results: had a lower expression in both mouse and human samples, targeted by an upregulated microRNA (miRNA) called has-miR-106a-5p, which may relate to hyperandrogenemia. Conclusions: play important roles in the pathological process of PCOS and have the potential to be diagnostic markers and therapeutic targets.

Source: Reproductive Medicine and Biology

DOI: 10.1002/rmb2.12664

Authors: Yicen Ding, Lishi Huang, Mengju He, Fei Zhang, Yuanjun Jiang, Yani Kang

Institution: Shanghai Jiao Tong University

Language: English

Topic: Ovarian function and disorders

Subfield: Reproductive Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,850